Among the numerous DDR proteins that are dysregulated in cancer, the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs, referred to here as DNA-PK) plays a pro-tumorigenic role in many types of cancer including prostate, breast, colorectal, and cervical cancers, as well as chronic leukemias [6,7,8]. This evidence concerns the gene PRKDC and cervical cancer.