TLR4 and Immunodeficiency: Four families of AMPs (abaecin, apidaecin, defensins, and hymenoptaecin) coordinate with each other to ward off viral, bacterial, fungal, and protozoon pathogens in honeybees and are regulated by the Toll and Imd/JNK (immune deficiency and Jun N-terminal kinase) pathways, which are two important intracellular signaling pathways in insects [34].