This study aimed to investigate the effects of SARS-CoV-2 on CML cells in vitro, with a particular focus on the potentially protective role of VK2 in mitigating SARS-CoV-2-induced cytotoxicity and enhancing the efficacy of ABL1-TKIs. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.