On the other hand, a few works [63,64,65] suggested the neuroprotective function of hippocampal astrocytic NMDARs since pharmacological antagonism of GluN2A and GluN2B or knockdown of Grin2a gene exacerbates β-amyloid (Aβ)-induced synaptotoxicity and cognitive decline. The gene discussed is GRIN2A; the disease is Mental deterioration.