Regarding whether phosphorylation of Dicer at different sites has different effects, compared to previous research in our laboratory, it was found that phosphorylation of Dicer at S1016 in pancreatic cancer cells resistant to gemcitabine also regulates specific miRNAs, affecting glutamine metabolism and leading to gemcitabine resistance. The gene discussed is DICER1; the disease is familial pancreatic carcinoma.