Zfp106, an RNA-binding protein essential for motor neuron survival, suppressed neurotoxicity in a Drosophila model of c9orf72 ALS by binding and causing a conformational change in the RNA G-quadruplexes formed by GGGGCC repeats, thus inhibiting RNA foci formation and reducing DPR levels. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.