Overexpression of S100B is observed in various conditions, including Down syndrome [12], Alzheimer’s disease [13], epilepsy [14], Parkinson’s disease [15], multiple sclerosis [16], schizophrenia [17], cerebral palsy [18], Creutzfeldt–Jakob disease [19], autism spectrum disorder [20], and also in COVID-19 [21]. The gene discussed is S100B; the disease is COVID-19.