Being an endothelial-independent blood supply system, based on tumor cell plasticity, the formation of vascular-like structures in VM relies on a complex network of intracellular signaling such as the vascular endothelial growth factor (VEGF) pathway, detected in GBM tissue samples and glioma stem cells (GSCs), and related to self-renewal, tumorigenicity, and tubular formation [13]. The gene discussed is VEGFA; the disease is central nervous system cancer.