Also, NOD1 and RIPK2 were found to be increased in response to intracerebral hemorrhage (ICH) and contributed to microglial activation and the inflammatory response, while either inhibition of NOD1 with ML130 (a highly selective inhibitor of NOD1) or RIPK2 with GSK583 (a specific RIPK2 inhibitor) alleviated the ICH-induced brain damage, microglial activation, and inflammatory response in mice [13]. This evidence concerns the gene RIPK2 and intracerebral hemorrhage.