Using the same method to search for HIV-R hub DEGs, we searched for HIV+ hub DEGs and identified nine hub genes (JUN, BUB1B, RAD51, RRM1, GATA1, ERBB2, IRF4, UBA5, and FBXO7) among the DEGs of EXP-Blood-HIV-Infection (Figure S13) and 16 hub genes (JUN, PLEK, CXCL8, MYC, TYROBP, CCL5, MPO, IL1B, CYBB, GZMB, CCL4, CD68, CD69, PTGS2, CD38, and CD274) in EXP-CD4-HIV-Infection (Figure S14). This evidence concerns the gene IRF4 and HIV infectious disease.