Interleukin (IL)-1α, IL-1β, and tumor necrosis factor (TNF) secreted from diffuse-type GC cells induce very high expression of rhomboid 5 homolog 2 (RHBDF2) in gastric stromal fibroblasts, leading to increasing motility in the ECM and promoting the invasion of diffuse-type GC cells [14]. The gene discussed is RHBDF2; the disease is gastric cancer.