MAPK8 and gastric cancer: Meanwhile, recent studies have revealed that in GC cells, CAFs-derived IL-8 caused cisplatin resistance in GC by activating NF-κB and upregulating the ATP-binding cassette and sub-family B (ABCB1) [36], and it increased the expression of PD-L1 via the NF-κB, p38, and JNK signaling pathways [37].