Furthermore, in the AD mice, the neurons in the hippocampus were loosely arranged, with some wrinkled cells and fewer Nissl bodies in the HS group (P < 0.001), and there were fewer NeuN-positive cells in the CA1 region of the hippocampus in the HS group compared with the ND group (P < 0.001, Figure 3F,G). Here, RBFOX3 is linked to Alzheimer disease.