PKM and Alzheimer disease: These mice exhibited changes in Hsc70, PKM2, LC3 I, and LC3 II levels and in the LC3 II/LC3 I ratio similar to those observed in HFD-induced AD mice (Figure 6F,G and Figure S6B, p < 0.05, p < 0.05, p < 0.05, p < 0.05, p < 0.01).