Treatment of HepG2 and Huh7, another liver cancer cell line, with 10, 15, and 30 μM of prunetin 4′-O-glucoside induced intrinsic apoptosis through the release of cytochrome c and activation of caspase-3 and 9, as well as an increase in bak and a decrease in Bcl-xL [82] (Figure 5). The gene discussed is CASP3; the disease is liver cancer.