ESR1 and breast carcinoma: In the study of Hwang, S.T., et al., treatment with genistin at 50, 100, and 150 μM inhibited estrogen receptor alpha (ERα), activated caspase-8 and 9, and caused cell death through PARP cleavage in MCF-7 cells, a breast cancer cell line, as shown in Table 1 [60].