CD38 and precursor B-cell acute lymphoblastic leukemia: The presence of LIC in different immunophenotypical populations has also been reported by Kong et al. and Jiang et al. Kong et al. showed that CD34+CD38+CD19+ or CD34+CD38−CD19+ cells from three B-ALL pediatric samples were able to develop B-ALL in experimental mice, while Jiang and colleagues showed that CD34+CD38−, CD34+CD38+, and CD34−CD38+ from B-ALL adult patients could reconstitute B-ALL in a mouse model [3,29].