We did not find any significant differences between the protein levels of p27Kip1 and/or cyclin D2 in patient cohorts divided based on genetic determinants of the outcome of CLL, except for the CDKN1Brs36228499CC and CDKN1Brs34330CC genotypes determining progressive CLL. The gene discussed is CCND2; the disease is B-cell chronic lymphocytic leukemia.