Of note, we found relationships between the genotypes non-predisposing to CLL, namely CDKN1Brs36228499CC, CDKN1Brs2066827TT, and CDKN1Brs34330CC, within the p27Kip1 pathway, as well as the CCND2rs3217901AG genotype and an aggressive course of CLL. Here, CDKN1B is linked to B-cell chronic lymphocytic leukemia.