In line with the above suggestion, our logistic regression analysis revealed the opposite predictive significance of B and T cell apoptosis; the rate of apoptosis of T cells increases with CLL progression and is associated with other clinically poor prognostic factors such as IgVH unmutated status, high WBC and lymphocyte counts, and increased β2-microglobulin levels. The gene discussed is HLA-G; the disease is B-cell chronic lymphocytic leukemia.