The high prevalence of the CDKN1Brs34330T or CCND2rs3217810T alleles found in our cohort of CLL patients appears to confirm the latter suggestion, as those polymorphisms are associated with a decrease in p27Kip1 or an increase in cyclin D2 gene induction [47,71,72,73], respectively, which could be indicative of improved cell proliferative potency in addition to apparent longevity in CLL. The gene discussed is CDKN1B; the disease is B-cell chronic lymphocytic leukemia.