CDKN1B and cancer: Thus, a number of single-nucleotide polymorphisms (SNPs) of the CDKN1B gene located within the 12p13.1-p12 chromosome encoding the p27Kip1 protein have been investigated and found to be related to either regulation of p27Kip1 protein expression or susceptibility to various cancers [44,45,46,47,48,49,50,51,52,53,54].