The suppression of the Slc6a1 gene, which encodes the GAT-1 transporter, in INS-treated APP/PS1 mice is associated with impaired GABA and taurine reuptake by astrocytes, contributing to the BDNF/TrkB/GABAergic excitatory extrasynaptic response [78] and disrupted E/I balance in AD [56]. Here, APP is linked to Alzheimer disease.