In line with these findings, different studies in rat models of endotoxin-induced acute renal failure have shown that PAR2 inhibition can normalize LPS-induced elevation of renal endothelin-1 and TNF-α, suggesting that blockade of PAR2 may play a crucial role in treating renal injury, via normalization of inflammation, coagulation, and vasoactive peptides [19,20]. The gene discussed is F2RL1; the disease is acute kidney injury.