It has been observed that the main products of Nrf2 transcriptional activity, heme oxygenase-1 (HO-1), as well as NAD(P)H:quinone oxidoreductase 1 (NQO1) [188], can undergo overexpression in melanoma [189], influencing its development by increasing cell proliferation and resistance to oxidative stress and therapy [190,191]. The gene discussed is NFE2L2; the disease is melanoma.