BRAF and neoplasm: Notably, tumor alterations in this variant exhibit a heightened frequency of mutations within the cell cycle regulating genes like neurofibromin 1 (NF-1), proto-oncogene tyrosine-protein kinase (ROS-1), neuroblastoma RAS viral oncogene homolog (NRAS), tyrosine-protein kinase KIT (KIT), and v-Raf murine sarcoma viral oncogene homolog B (BRAF) [23].