The cytoHubba plugin identified twenty-one hub genes associated with ovarian cancer, namely TEN1, FN1, LSM11, SMCO4, ACD, PLEKHS1, TERT, CYREN, CLPTM1L, SEMG2, MIA, ITGAD, FSD1L, FNDC4, LACRT, CTC1, RIMBP3B, MKRN1, ITGA10, SFTPC, and WRAP53, based on their elevated degree scores, the STRING online database was used to construct the PPI network of the key genes. This evidence concerns the gene PLEKHS1 and ovarian carcinoma.