CDK5RAP3 and melanoma: The differentially expressed genes between CECs isolated with the EpCAM mAb- versus cmHsp70.1 mAb-conjugated bead approach are related to the proto-oncogene Src and kinases (SRC and FGR) [26], cell cycle regulators (RGCC, CDK5RAP3 and CDKN1A), matrix metalloproteinases (MMP2-ASI) [27] (Table 2), which regulate tumor progression and invasiveness via cytoskeletal reorganization and extracellular matrix remodeling, and cell adhesion and migration (ITGAM and ITGAE) in human melanoma [28].