Further insights into the involvement of Hsp70 in the progression of ovarian cancer have been provided by studies demonstrating that the inhibition of Hsp70 nuclear translocation and interruption of its interaction with Notch1’s intracellular domain reduces the migratory and invasive capacity of the OVCAR3 serous ovarian cancer cell line and the growth of OVCAR3-derived tumors in vivo [40]. This evidence concerns the gene NOTCH1 and ovarian serous adenocarcinoma.