CCL2 and experimental autoimmune encephalomyelitis: Experimental autoimmune encephalomyelitis (EAE) models illustrate the astrocyte upregulation of transcription factors for inflammatory mediators, notably C-C motif chemokine ligand 2 (CCL2), CCL5, C-X-C motif chemokine ligand 10 (CXCL10), iNOS, and TNF, but conversely, reducing anti-inflammatory cytokines IL-10 and IL-27 when compared to control mice [134].