MDH2 and hepatocellular carcinoma: Figure 2C shows that the knockdown of MDH2 significantly promoted RSL3-induced HCCLM3 and HLE cell death. Additionally, to validate this finding, we stably overexpressed MDH2 in HCC cells (Figure 2D) and found that MDH2 overexpression impeded RSL3-induced HCC cell death (Figure 2E,F).