To explore the function of MDH2 in HCC, firstly, we analyzed the expression of MDH2 using UALCAN (https://ualcan.path.uab.edu/analysis.html, accessed on 24 October 2024) and found that MDH2 was upregulated in HCC tissue samples compared with normal control tissues (Figure 1A). This evidence concerns the gene MDH2 and hepatocellular carcinoma.