In addition, TLR4 displays an important role in the central nervous system by mediating the activation of the inflammatory nuclear factor-κB (NF-κB), as documented in several neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s diseases, and Amyotrophic Lateral Sclerosis [35]. Here, NFKB1 is linked to amyotrophic lateral sclerosis.