NFE2L2 and Friedreich ataxia: Oxidative stress in FRDA is most likely the result of a mitochondrial reactive oxygen species (ROS) overload generated by the iron-mediated Fenton reaction, and by an impaired signaling of the master antioxidant regulator nuclear factor erythroid 2-related factor 2 (NRF2) [10,11,12,13,14,15,16,17].