There is also much research on the role of flavonoids in lung cancer, which have antitumoral effects through a wide range of molecular mechanisms, such as cyclin-dependent kinase 1 (CDK1), proliferating cell nuclear antigen (PCNA), and nuclear transcription factor kappa B (NFκB), or inhibiting PI3K/Akt/mTOR, ERK, and Wnt/β-catenin. The gene discussed is PCNA; the disease is lung cancer.