Although NDGA did not cause a significant increase in the G1/S cell population in H1299 or A549 cells, a possible explanation for the antiproliferative effect on these cell lines can be partially explained by the decrease in GSDME protein levels (Figure 3), since it has been described that the knockdown of GSDME in A549 and H1299 cells (and other NSCLC cell lines) decreased the proliferation of these cells in vitro [43]. This evidence concerns the gene GSDME and non-small cell lung carcinoma.