C3 and IgA glomerulonephritis: They further showed 23b−/− mice developed an IgA nephropathy-like phenotype of mesangial IgA and C3 deposition associated with the development of albuminuria, hypertension, and elevated serum creatinine, suggesting that loss of miR-23b is indispensably associated with IgA nephropathy [126] (Figure 2).