TNF and skin disorder: Chronic inflammatory responses were thought to be a major cause of dermatitis; indeed, a medicine derived from fermented black soybean [Glycine max (L.)Merr.] has been shown to lighten atopic dermatitis via decreasing PKC and IL-4 in mice [17], with the authors finding that the decreased PKC and IL-4 were associated with the down-regulation of inflammatory-related cytokines, such as interleukins and TNF-α.