MEN1 and tumor of parathyroid gland: Specifically, MEN1 parathyroid tumors still having the wild-type allele of the MEN1 gene may exhibit miR-24-1-increased levels in association with the menin complete silencing, thus suggesting a direct miR-24-1-dependent inhibition on MEN1-mRNA translation, suggesting that such epigenetic events may drive toward an intermediate molecular step before the genetic LOH of the wild-type MEN1 allele occurs, consequently inhibiting the menin expression and triggering MEN1 parathyroid tumorigenesis by mimicking the “Knudson’s second inactivating hit” on the MEN1 gene expression [63].