NOS3 and lung carcinoma: Moreover, PRMT5, desuccinylated by SIRT7 [50], maintains the activation and stabilization of HIF-1α, which is essential to the phosphorylation of VEGFR2 as well as downstream Akt and endothelial nitric oxide synthase (eNOS) in lung cancer cells and ECs, playing a significant role in angiogenesis [53,54].