TNF and hepatocellular carcinoma: In HCC, SIRT7 desuccinylates, thereby activating and stabilizing PRMT5 [50], where the latter is essential for NF-κB activity and the expression of its target genes, including tumor necrosis factor-alpha (TNF-α) and VEGFA in neovascular age-related macular degeneration and laser-induced choroidal neovascularization models [52].