Whilst there was no difference in HAO1 mRNA expression associated with ER or PR in the METABRIC dataset (Figure 4A,C,E; p > 0.05), there was a significant association between high HAO1 mRNA expression and ER negative and PR negative tumours in bc-GenExMiner (Figure 4B,D,F; all p < 0.0001). This evidence concerns the gene HAO1 and neoplasm.