The MTSS1 gene could be epigenetically regulated since previously, studies had shown that the methylation of the MTSS1 promoter in bladder cancer cell lines correlated with MTSS1 silence and that increased MTSS1 promoter methylation in gastric cancer cell lines and tissue samples reduced endogenous MTSS1 expression [24]. Here, MTSS1 is linked to urinary bladder carcinoma.