Interestingly, we verified that Mecp2 deficiency determines a mitochondrial O2•− overload that is significantly reduced upon GM1-OS administration (Figure 2), confirming the antioxidant properties of GM1-OS observed in Parkinson’s [40,46] and Amyotrophic Lateral Sclerosis neuronal models [48]. This evidence concerns the gene MECP2 and amyotrophic lateral sclerosis.