A total of 44 sporadic variants, including missense, silent, nonsense, and splice alterations, have been reported in CSMD1 (CUB and Sushi multiple domains 1, MIM# 608397) in individuals with developmental disorders and autism [17,20,34,37,38,39,40], suggesting that CSMD1 is likely an autism disorder gene. Here, CSMD1 is linked to autism.