GP1BA and Sepsis: To further prove that the GPIbα cytoplasmic tail in platelets regulates the lifespan of mice with sepsis, we transfused WT and 10aa−/− platelets to Mpl−/− mice, which have low platelet counts but normal GPIbα expression in platelets (Figure S2B), and found that 10aa−/− platelet transfusion significantly extended survival compared with WT (Figure 2F).