Short pentraxins, including the acute-phase proteins PTX1 (CRP) and amyloid components PTX2 (SAP), are produced by the liver in response to bacterial and viral infections, and in case of the release of endogenous components of the cells, e.g., in the course of tissue necrosis or under the stimulation of IL-1 and IL-6, they are widely used in clinical practice as non-specific indicators of the intensity of the immune response. This evidence concerns the gene CRP and viral infectious disease.