Myocardin-related transcription factor A (MRTF-A), the co-activator of serum response factor (SRF), has been shown to be induced by the Wnt-β-Catenin signaling pathways and to promote COL1A1 expression by directly regulating chromatin acetylation and recruiting RNA polymerase II to the COL1A1 promoter in human breast cancer cells [55]. This evidence concerns the gene COL1A1 and breast cancer.