MED12 and leiomyoma: Moreover, genomic studies have identified chromosomal rearrangements and mutations associated with leiomyoma development and progression, including mutations in MED12 (Mediator Complex Subunit 12), HMGA2 (High-Mobility Group AT-Hook 2), FH (Fumarate Hydratase), and COL4A5/6 (Collagen Type IV Alpha 5 and Alpha 6) [4,5,6].