The inhibition of ZKSCAN3 using shRNA in MCF-7 and MDA-MB-231 cells diminishes cell viability, migration, and invasion, highlighting that ZKSCAN3-shRNA significantly decreases the expression of MMP-2, MMP-9, CCND1, and Bcl-2 while augmenting the expression of Bax in breast cancer cells [22]. The gene discussed is ZKSCAN3; the disease is breast cancer.