CEACAM5 and colorectal neoplasm: Additionally, a study of 450 individuals with sporadic CRC revealed a correlation between ZKSCAN3 alleles and male gender, family history of malignancy, high blood CEA concentration, and stage IV CRC, suggesting that ZKSCAN3 contributes to the progression and infiltration of colorectal tumors, especially facilitating CRC metastasis to the liver, particularly in CEA-producing tumors [43].