Remarkably, from the transcriptomic analysis performed on AML patients (stratified based on PFKM/MAP1LCB/BNIP3 expression) emerges that those with low glycolysis and active autophagy–mitophagy (displaying a better prognosis) exhibit a downregulation of a subset of genes required for the correct maturation and proliferation of myeloid cells, lactate/pyruvate transporters, multidrug efflux transporters, and evasion from programmed cell death. This evidence concerns the gene PFKM and acute myeloid leukemia.