Many BD-associated SYNE1 mutations have been identified in both the coding and promoter regions of the CPG2 locus, and mutations in the promoter region negatively regulate CPG2 transcription [28,96], while several mutations in the coding region attenuate the synaptic localization of the CPG2 protein and the internalization of AMPAR [96]. Here, SYNE1 is linked to Behcet disease.