Moreover, recent studies have demonstrated that in motor neurons, cortical neurons, and spinal cord organoids harboring the ALS-causative C9ORF72 mutation, which is most frequent in familial ALS, the LINC complex proteins, including SUN1/2 and Nesprin-1/-2, mislocalize to the cytoplasm, causing morphological alterations of the nucleus [101]. The gene discussed is SYNE1; the disease is amyotrophic lateral sclerosis.