In this condition, almost 30 different proteins are able to form deposits [10], but the most frequent involved are transthyretin and misfolded monoclonal immunoglobulin light chains, which bring two clinical conditions called transthyretin amyloidosis (ATTR) and light-chain amyloidosis (AL) [7,8,9]. The gene discussed is TTR; the disease is Familial transthyretin-related amyloidosis.