NFE2L2 and non-small cell lung carcinoma: Moreover, curcumin may act as an NRF2 inhibitor by upregulating PTEN (phosphatase and tensin homolog deleted on chromosome ten), which results in overcoming MDR in lung cancer, or by activating KEAP1, resulting in higher NRF2 polyubiquitination, which reverses cisplatin (DDP) resistance in non-small-cell lung cancer A549/DDP cells (Table 1) [2,24,25].