NFE2L2 and malignant colon neoplasm: Applying NRF2 inhibition by trigonelline (500 nM), trigonelline-loaded 3Block (PCL-PEG-PCL) (500 nM) and trigonelline-loaded 5Block (PLA-PCL-PEG-PCL PLA) (500 nM) micelles caused an almost 2-fold decrease in NRF2 mRNA expression in resistant colon cancer cells.