This has been exemplified in a study where pretreatment of non-small-cell lung cancer (NSCLC) A549 and NCIH460 cell lines with trigonelline caused lower expression of NRF2-dependent genes such as HO-1 and NQO1, while the level of cellular NRF2 remained unchanged [7,47]. Here, NFE2L2 is linked to non-small cell lung carcinoma.