Isoliquiritigenin (2′,4,4′-trihydroxychalcone) isolated from Glycyrrhiza uralensis is a phenolic compound which was able to inhibit NRF2 activity by upregulating KEAP1 transcription and expression, resulting in the promotion of NRF2 degradation in human liver cancer HepG2 cells and leading to lowered levels of NRF2-dependent antioxidants [4,72]. Here, NFE2L2 is linked to liver cancer.