Additionally, α1KICD89Tg mice fed a gluten-free diet for three generations showed substantial reductions in mesangial IgA1 deposition and hematuria, along with a loss of the IgA1-soluble CD89 (sCD89) complex, and decreases in the mesangial expression of CD71 and transglutaminase 2 [43]. This evidence concerns the gene IGHA1 and Hematuria.