MAP3K14 and metabolic disease: In this regard, recent research has emphasized the involvement of NIK in metabolic disease [49,50,51], sarcopenia [52], liver disease [22,53,54], malignancy [55,56,57,58,59,60,61,62,63,64,65], sepsis [46], neurological disease [45], and inflammation of multiple organs [66], including immune-mediated vasculitis and complement-mediated endothelial cell injury [37,48,67].