In vivo, one report demonstrated that the endothelial-specific deficiency of NIK IRF-1 attenuated atherosclerosis in high-fat diet-fed Apoe-null mice [39], and another indicated the need for NIK in lymphatic endothelial cells to activate the non-canonical NFκB pathway to regulate B-cell homing to lymph nodes [41]. The gene discussed is IRF1; the disease is atherosclerosis.