By contrast, long-term NIK inhibition is associated with immune deficiency: Patients with autosomal recessive NIK deficiency or deficiency in the other members of the pathway such as RELB or NFκB2 may develop neutralizing autoantibodies against type I interferons and are at higher risk of life-threatening COVID-19 pneumonia [34]. This evidence concerns the gene MAP3K14 and hyperinsulinemic hypoglycemia, familial, 4.