NFKB1 and metastatic malignant neoplasm in the lymph nodes: The clinico-pathological correlation between nuclear RelA localization and BRAFV600E expression in a large cohort of highly malignant PTC cases [21], and the finding that enhanced BRAFV600E expression and constitutive NF-κB activity in tissues from PTC patients could represent a risk factor for the development of cervical lymph node metastasis [53], confirmed the pivotal role of NF-κB in mediating the aggressive behavior of BRAFV600E-positive PTCs (Figure 3).