Its role in NF-κB-dependent thyroid cancer has been discovered and characterized for the first time in ATCs [56], where NGAL is not only strongly expressed but significantly contributes to ATC cell survival through FAS/CD95 down-regulation [57] and increases their metastatic propensity through MMP-9 enzymatic activity enhancement [58]. This evidence concerns the gene NFKB1 and thyroid gland carcinoma.