Thus, it has been shown that transcription of thyroid peroxidase (TPO), a specific enzyme of differentiated thyroid follicular cells involved in the iodine organification process and one of the most common antigens linked to thyroid autoimmunity, is induced by lipopolysaccharide (LPS) through NF-κB p65/RelA phosphorylation of serine 536. The gene discussed is NFKB1; the disease is autoimmune thyroid disease.