NFKB1 and cancer: Interestingly, NF-κB persistent activation in cancer cells could also be triggered by dysregulated signaling from PI3K/AKT, MAPK, JAK/STAT, TGF-β, Wnt, Notch, and Hedgehog pathways, which may exert their protumorigenic role through crosstalk with different components of NF-κB pathways [24].