In particular, given the well-defined role of specific oncogenes (RET/PTC and BRAFV600E) and tumor suppressor genes (PPARγ and PTEN) in thyroid carcinogenesis, different studies aimed to investigate NF-κB involvement in the regulation of the main pathways triggering thyroid carcinoma development and progression. This evidence concerns the gene NFKB1 and thyroid gland disorder.