Notably, in a cohort of 840 LVNC patients, a very small subset of mutations, particularly truncating variants in MYH7, were highly enriched in LVNC patients relative to controls or those with HCM and DCM, suggesting that a small subset of mutations within known cardiomyopathy genes either cause or act as modifiers to produce the LVNC phenotype [212]. This evidence concerns the gene MYH7 and left ventricular noncompaction.