Interestingly, it has been previously shown that the expression of FXR and its downstream-regulated genes such as ASBT are upregulated in the GATA4 null mice jejunum [46], which suggests that GATA4 might regulate the altered expression of both ASBT and FXR along the proximal length of the small intestine in obesity. Here, SLC10A2 is linked to obesity due to melanocortin 4 receptor deficiency.