Following the network construction of the protein–protein interaction, AKT1, IL6, TP53, MMP9, ESR1, NFKB1, MTOR, IGF1R, ALB, and NFE2L2 were recognized as the top 10 hub genes by analyzing the 45 key intersecting targets in the protein–protein interaction network of Citri Reticulatae Pericarpium and sarcopenia. The gene discussed is ESR1; the disease is sarcopenia.