Neutrophils release more NETs into the circulation in patients with cancer, and these can activate platelets and can synergistically, together with TF-bearing extracellular vesicles assembling on a negatively charged phospholipid surface, create a thrombin burst that not only causes thrombosis but may also promote angiogenesis and tumor metastasis, as reviewed by [103]. The gene discussed is TF; the disease is cancer.