At 3, 6, and 12 months of age, 26.3% (vs. 0% in WT, p = 0.02, n = 39), 31.6% (vs. 0% in WT, p = 0.02, n = 39), and 61.9% (vs. 0% in WT, p < 0.0001, n = 41) of non-diabetic ChREBP-KO mice showed one or more neoplasms, including RCC. Here, MLXIPL is linked to renal cell carcinoma.