APOB and metabolic syndrome: The phenotype of individuals with biallelic pathogenic variants in LIPC is a complex combined dyslipidemia with marked elevations in total, LDL, and HDL cholesterol, triglycerides, and Apo B as well as the presence of beta-migrating very-low-density lipoprotein (VLDL), which can be considered functionally equivalent to intermediate density lipoprotein (IDL), as well as abnormal TG enrichment of LDL and HDL species [7,10].